ABO-mismatched platelet and plasma transfusion practices and the potential for transfusion-related alpha-gal syndrome (TRAGS): the Biomedical Excellence for Safer Transfusion (BEST) Collaborative Study

Article Title: ABO-mismatched platelet and plasma transfusion practices and the potential for transfusion-related alpha-gal syndrome (TRAGS): the Biomedical Excellence for Safer Transfusion (BEST) Collaborative Study

CME Editor: Julie Katz Karp; sent to reviewer Dr. Anne Eder ([email protected])

Article Authors: Dunbar NM, Kaufman RM, Bary KS, Bellairs GRM, Cohn CS, Delettre F, Ditcham S, Duarte GC, Ellison A, Fachini R, George CE, Humbrecht C, Louw V, Meier S, Morley S, Mwase M, Robitaille N, Rushford K, Sato T, Schafer R, Staves J, Takanashi M, Tiberghien P, Wendel S, Wood EM, Ziman A, and Murphy MF

If you wish to receive credit for this activity, please refer to the website: https://www.wileyhealthlearning.com/trf

Educational Objective: Explore the frequency of group B and AB plasma and platelet transfusions to group O patients as it might apply to the potential for transfusion-related alpha-gal syndrome

Release Date: 10 September 2025

Activity Disclosures

No commercial support has been accepted related to the development or publication of this activity.

CME Editor, Julie Katz Karp MD reported no conflicts of interest or financial relationships relevant to this article. This activity underwent peer review in line with the standards of editorial integrity and publication ethics. Conflicts of interest have been identified and resolved in accordance with John Wiley and Sons, Inc.’s Policy on Activity Disclosure and Conflict of Interest.

Accreditation
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John Wiley and Sons, Inc. designates this journal-based CME activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should only claim credit commensurate with the extent of their participation in the activity. For information on applicability and acceptance of continuing medical education credit for this activity, please consult your professional licensing board.

This activity is designed to be completed within 1 hour. To successfully earn credit, participants must access the activity on https://www.wileyhealthlearning.com and complete the activity during the valid credit period, which is up to three years from initial publication. Additionally, up to 3 attempts and a score of 70% or better is needed to pass the post test and claim CC credit. [ACGME competency/CC category: Medical Knowledge].