Addressing the unmet needs in pediatric mild-moderate atopic dermatitis: the role of PDE-4 inhibitors

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Article Title: Efficacy and Safety of Once-Daily Roflumilast Cream 0.05% in Pediatric Patients Aged 2–5 Years With Mild-to-Moderate Atopic Dermatitis (INTEGUMENT-PED): A Phase 3 Randomized Controlled Trial

Article Authors: Lawrence F. Eichenfield, Rocco Serrao, Vimal H. Prajapati, John C. Browning, Lisa Swanson, Tracy Funk, Mercedes E. Gonzalez, Adelaide A. Hebert, Mark Lee, Mark Boguniewicz, Eric L. Simpson, Melissa S. Seal, David Krupa, Diane Hanna, Scott Snyder, Patrick Burnett, David H. Chu, Erin Almaraz, Robert C. Higham, David R. Berk

Educational Objective:

1. Enhance healthcare professionals’ knowledge on PDE4 inhibitor based therapeutic options for treatment of mild-to-moderate atopic dermatitis in children.

2. Enhance healthcare professionals’ knowledge on the therapeutic potentials of PDE4 inhibitors by precise pharmacological adoption and combination therapy for treating atopic dermatitis.

Release Date: 1st December 2025

Activity Disclosures

This CME activity was sponsored by an educational grant from Arcutis Biotherapeutics Inc.

This activity underwent peer review in line with the standards of editorial integrity and publication ethics. Conflicts of interest have been identified and resolved in accordance with John Wiley and Sons, Inc.’s Policy on Activity Disclosure and Conflict of Interest.

Accreditation
John Wiley & Sons, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

John Wiley and Sons, Inc. designates this journal-based CME activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should only claim credit commensurate with the extent of their participation in the activity. For information on applicability and acceptance of continuing medical education credit for this activity, please consult your professional licensing board.

This activity is designed to be completed within 1 hour. To successfully earn credit, participants must access the activity on https://www.wileyhealthlearning.com and complete the activity during the valid credit period, which is up to three years from initial publication. Additionally, up to 3 attempts and a score of 70% or better is needed to pass the post test and claim CC credit. [ACGME competency/CC category: Medical Knowledge].